J Anesth Perioper Med. 2015;2(1):29-35. https://doi.org/10.24015/ebcmed.japm.2015.0005
From the Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
Correspondence to Dr. Jin Liu at firstname.lastname@example.org.
EBCMED ID: ebcmed.japm.2015.0005 DOI: 10.24015/ebcmed.japm.2015.0005
Aim of review
This review describes the multi-organ protective effects of emulsified isoflurane.
This review examines the recent experimental researches involving emulsified isoflurane-induced preconditioning and postconditioning in multiple organs.
Emulsified isoflurane is a new formulation of isoflurane in lipid emulsion. It enables an intravenous, intraperitoneal injection or oral (rather than the traditional inhalation) route of administration for this anesthetic. Pharmacological preconditioning and postconditioning by using inhalation isoflurane have been demonstrated to be the protective strategies in clinical settings for the high risk patients with various organ dysfunctions. In recent years, there has been increased interest in exploring the protective effect of emulsified isoflurane in multiple organs including heart, brain, kidney, liver and lung, providing potential approaches translating these convincing experimental conditioning effects to clinical practice.
Emulsified isoflurane could exert strong organ-protective effects. With an understanding of its potential mechanisms, therapeutic approaches may be applied to the future organ-protective properties, transferring convincing experimental evidences into clinical therapies.
Declaration of Interests
No other potential conflicts of interest relevant to this review was reported.
This study was supported by Grant No. 30901412 from the National Natural Science Foundation of China.
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