J Anesth Perioper Med. 2017;4(1):35-44. https://doi.org/10.24015/ebcmed.japm.2017.0005
From Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
*Contributed equally to this work.
Correspondence to Dr. Xiang-Ming Fang at xiangming_fang@163.com.
EBCMED ID: ebcmed.japm.2017.0005 DOI: 10.24015/ebcmed.japm.2017.0005
Aim of review
To provide a new direction for clarifying the pathogenesis of sepsis and seeking efficient prevention and treatment for sepsis.
Methods
The articles and literature regarding metabolic change of immune cells and/or its role in sepsis published in the last five years were retrieved from PubMed and Web of Science. A basic search was performed using keywords of sepsis, immunity, immune cells, metabolism, etc. In addition, some classical researches and reviews were also referenced.
Recent findings
The cellular metabolism dictates the fate and function of the immune cells, which plays a key role in the occurrence and development of sepsis. Since the immune cells are activated, the cellular metabolism switches from oxidative phosphorylation to aerobic glycolysis (the Warburg effect). The Warburg effect of monocytes/macrophages is the metabolic basis not only for stimulating the inflammatory response but also for trained immunity. In addition, the Warburg effect also contributes to the maturation of dendritic cells and the activation and differentiation of T cells. Studies have shown that the immune cells from septic patients had an impaired ability to stimulate the Warburg effect.
Summary
The immune state of the host is closely related to the metabolism of immune cells. Since cellular metabolism is amenable to pharmacological modulation, further elucidation of this mechanism may provide novel treatment strategies for sepsis. Whether regulating the Warburg effect could help patients survive from sepsis that needs to be further researched.
Article Type
Review Article
Declaration of Interests
The authors have no potential conflict of interest for this review to declare.
Acknowledgements
This work was supported by the National Natural Science Foundation of China (grant 81301653).
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