Original Research

Short Postnatal Exposure to Sevoflurane Does Not Cause Evident Neurotoxicity in Rats

Hai-Lin Zhao , Da-Qing Ma , Niccolò Terrando
Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK, Department of Anesthesiology, Basic Science Division, Duke University Medical Center, Durham, North Carolina, USA
J Anesth Perioper Med 2016; 3(2): 57- 62 . Published on Mar 16, 2016 . doi:10.24015/JAPM.2016.0008
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Abstract

Background: Recent evidence has raised concerns about some anesthetic drugs causing memory and learning difficulties and other harmful changes in the central nervous systems of children. The long-term effects of anesthetics exposure on normal brain development remain controversial. In this study, we investigated both acute and long-term effects of clinically relevant anesthesia on two distinct phases of brain development.

Methods: Postnatal day (PD) 7 and PD15 Wistar male rats were exposed to 30 minutes of 2.5% sevoflurane anesthesia. Cell death in the hippocampus and cortex was evaluated 6 hours after exposure. Long-term neuroinflammatory changes were assessed histologically after 3 months.

Results: Sevoflurane exposure at 2.5% for 30 minutes did not cause evident physiological changes in PD7 and PD15 rats. Apoptosis, as measured by cleaved caspase-3 as early as 6 hours after sevoflurane exposure, was not observed in the hippocampus or cortex. Microglia and astrocytes morphology was not significantly affected in either group 3 months after exposure.

Conclusions: Overall, these results suggested that brief exposure to a clinically relevant anesthetic, sevoflurane, does not cause significant neurotoxicity acutely and longer term.

 

 

Citation: Hai-Lin Zhao, Da-Qing Ma, Niccolò Terrando. Short postnatal exposure to sevoflurane does not cause evident neurotoxicity in rats. J Anesth Perioper Med 2016; 3: 57-62. doi: 10.24015/JAPM.2016.0008

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