Original Research

Short Postnatal Exposure to Sevoflurane Does Not Cause Evident Neurotoxicity in Rats

Hai-Lin Zhao , Da-Qing Ma , Niccolò Terrando
Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK, Department of Anesthesiology, Basic Science Division, Duke University Medical Center, Durham, North Carolina, USA
J Anesth Perioper Med 2016; 3(2): 57- 62 . Published on Mar 16, 2016 . doi:10.24015/JAPM.2016.0008
Figures & Tables
Author & Article info


Background: Recent evidence has raised concerns about some anesthetic drugs causing memory and learning difficulties and other harmful changes in the central nervous systems of children. The long-term effects of anesthetics exposure on normal brain development remain controversial. In this study, we investigated both acute and long-term effects of clinically relevant anesthesia on two distinct phases of brain development.

Methods: Postnatal day (PD) 7 and PD15 Wistar male rats were exposed to 30 minutes of 2.5% sevoflurane anesthesia. Cell death in the hippocampus and cortex was evaluated 6 hours after exposure. Long-term neuroinflammatory changes were assessed histologically after 3 months.

Results: Sevoflurane exposure at 2.5% for 30 minutes did not cause evident physiological changes in PD7 and PD15 rats. Apoptosis, as measured by cleaved caspase-3 as early as 6 hours after sevoflurane exposure, was not observed in the hippocampus or cortex. Microglia and astrocytes morphology was not significantly affected in either group 3 months after exposure.

Conclusions: Overall, these results suggested that brief exposure to a clinically relevant anesthetic, sevoflurane, does not cause significant neurotoxicity acutely and longer term.



Citation: Hai-Lin Zhao, Da-Qing Ma, Niccolò Terrando. Short postnatal exposure to sevoflurane does not cause evident neurotoxicity in rats. J Anesth Perioper Med 2016; 3: 57-62. doi: 10.24015/JAPM.2016.0008

This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Copyright © 2014-2018 | Evidence Based Communications (EBC)   All Rights Reserved.
Privacy Policy | Terms of Use | NIH Public Access Policy
ISSN: 2306-773X (Print) and 2520-3002 (Online)Submit a Manuscript | EBC and EBC Journals

The content on this site is intended for health professionals.