Original Research

Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

Hao Gao , Jin-Chao Song , Jin-Min Zhang , Ying-Fu Jiao , Zhi-Jie Lu , Tian-Zhu Tao , Wei-Feng Yu
Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China, Department of Anesthesiology, Air Force General Hospital of the Chinese PLA, Beijing, China
J Anesth Perioper Med 2017; 4(1): 1- 6 . Published on Dec 26, 2016 . doi:10.24015/JAPM.2017.0001
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Background: In this study, the effects of sevoflurane or propofol on immune function in patients undergoing partial hepatectomy were investigated during general anesthesia and after surgery.

Methods: Seventy-two patients undergoing hepatectomy were randomized into sevoflurane group or propofol group. Sevoflurane or target-controlled infusion (TCI) of propofol was separately used to anesthesia induction and maintenance of two groups. Venous blood samples were taken before induction, 2 hours after anesthesia and 2 hours after surgery for measurement of the percentages of T lymphocyte (CD3+, CD4+, CD8+) and NK cells.

Results: Compared with that before anesthesia induction, percentage change in CD3+ and CD4+ T cells to baseline was -0.7% and 3.8% in sevoflurane group, 10.2% and 20.2% in propofol group 2 hours after anesthesia (P=0.002 for CD3+ T cells and P=0.029 for CD4+ T cells ). Percentage change in NK cells was 17.6% in sevoflurane and -12.2% in propofol group 2 hours after anesthesia respectively (P=0.03). There was no significant difference in percentage change 2 hours after surgery of T cells and NK cells to baseline between two groups.

Conclusions: Our study indicates that use of propofol during general anesthesia tend to increase the percentages of peripheral CD3+ and CD4+ cells, while sevoflurane increase the peripheral NK cells.


Citation: Hao Gao, Jin-Chao Song, Jin-Min Zhang, Ying-Fu Jiao, Zhi-Jie Lu,Tian-Zhu Tao, et al. Effects of sevoflurane or propofol on immune function in patients undergoing hepatectomy. J Anesth Perioper Med  2017; 4: 1-6. doi: 10.24015/JAPM.2017.0001

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