Perioperative Use of Benzodiazepines: A Reconsideration of Risks and Benefits

Yanzi Zhang , Yidan Tang , Jing Yang , Chunyu Gong , Zhuo Li
Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Department of Surgery, NO. 4 West China Teaching Hospital, Sichuan University, Chengdu, China Department of Pharmacy, Shaanxi Provincial People's Hospital, Xi'an, China
J Anesth Perioper Med 2018; 5(1): 34- 40 . Published on Jan 31, 2018 . doi:10.24015/JAPM.2018.0010
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Aim of review: Reconsideration of Benzodiazepines (BZDs) after many years’ widespread use, for development of recent new similar drugs and consideration about increased delirium with BZDs.
Methods: A comprehensive search in OVID MEDLINE, EMBASE and PubMed were performed from inception to Jan 31, 2016, the studies which involved pharmacological characteristics of BZDs and comparison among BZDs, placebo and some similar new drugs used for sedation and antianxiety in the perioperative period were included. 
Recent findings: Routine use of BZDs as a sedative and antianxiety premedication is lack of benefits. BZDs did not improve the self-reported patient experience the day after surgery, but was associated with a lower rate of early cognitive recovery. Large numbers of using of other sedation drugs such as Propofol or Dexmedetomidine are replacing the using of BZDs for postoperative sedation. BZDs are important anesthesia-related predictors of postoperative delirium. Compared with those new drugs in sedation and anti-anxiety, BZDs has gradually lost its market.
Conclusion: As the developing of anesthesia monitoring technique and more beneficial pharmaceutical, the perioperative application of BZDs should be used with caution. (Funded by the National Natural Science Foundation of China.) 
Citation: Yanzi Zhang, Yidan Tang, Jing Yang, Chunyu Gong, Zhuo Li. Perioperative Use of Benzodiazepines: A Reconsideration of Risks and Benefits. J Anesth Perioper Med 2018;5:34-40. 
doi: 10.24015/JAPM.2018.0010

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