Perioperative Anaphylaxis and Chronic Inflammatory Diseases: The Role of Mast Cells

Qin Zhou , Yiwei Wang , Qingqing Qian , Hongquan Dong , Bo Gui , Yanning Qian
Department of Anesthesiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
J Anesth Perioper Med 2018; 5(5): 247- 252 . Published on Sep 28, 2018 . doi:10.24015/JAPM.2018.0090
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Aim of review: To provide a brief overview of the perioperative anaphylaxis and inflammation role of mast cells.
Methods: We searched the keywords “inflammation” or “anaphylaxis” or “perioperation” combined with “mast cells” in the Pubmed. A current review of original studies, systematic reviews, and meta-analysis within the past decade were included in the analysis.
Recent findings: Mast cells are observed around blood vessels in most tissues, therefore making them well-positioned to react quickly to internal and external environmental threats (stimuli). Mast cells are important in the regulation of the neuro-endocrine-immune network. Mast cells and their secreted mediators participate in a variety of physiological and pathological processes, such as perioperative anaphylaxis and central nervous system (CNS) inflammatory processes. In recent years, it has been recognized that mast cells are not only related to anaphylaxis, but also involved in the occurrence and development of acute central nervous inflammation after the operation.
Summary: The MCs play a key role in regulating normal physiological processes and many pathological conditions. The degranulation of mast cells could induce the anaphylaxis and inflammation. However, mast cells degranulation is unpredictable, so that the main concern is the avoidance of release of histamine and other MC mediators and the management of risks induced by mast cells. (Funded by the National Natural Science Foundation of China, Postgraduate Research & Practice Innovation Program of Jiangsu Province, and the Priority Academic Program Development of Jiangsu Higher Education Institutions.)
Citation: Qin Zhou, Yiwei Wang, Qingqing Qian, Hongquan Dong, Bo Gui, Yanning Qian. Perioperative Anaphylaxis and Chronic Inflammatory Diseases: The Role of Mast Cells. J Anesth Perioper Med 2018;5: 247- 252. doi10.24015/JAPM.2018.0090
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