Neuroendocrine-Immune Interaction in Lung Diseases

Jing Lin , Lei Du , Jerry Yu
Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China, Department of Pulmonary Medicine, University of Louisville, and Robley Rex VA Medical Center, Louisville, USA
J Anesth Perioper Med 2014; 1(1): 44- 49 . Published on Sep 10, 2014 . doi:10.24015/JAPM.2014.0007
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Aim of review: This overview describes neuroendocrine immune regulation of inflammation in the lung.

Method: The articles published in past 2 decades in this area were reviewed.

Recent findings: Pulmonary diseases are often associated with inflammation, which is  an essential body response to infection and injury. During inflammation, various cells are activated to release inflammatory molecules, modulating disease progression. Inflammation is regulated by the immune system, which interacts with the neuroendocrine system via the autonomic nerves and the hypothalamic-pituitary-adrenal axis. During lung diseases airway sensors are activated to produce host defense responses against inflammation, infection and trauma. 

Summary: These neural-mediated responses are immediate and non-specific. They  may amplify inflammation via local or axonal reflexes to enhance immune protection or  suppress inflammation via the central nervous system to avoid tissue destruction.


Citation: Jing Lin, Lei Du, Jerry Yu. Neuroendocrine-immune interaction in lung diseases. J Anesth Perioper Med 2014; 1: 44-49. doi: 10.24015/JAPM.2014.0007

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