Opinion

Surgery, Neuroinflammation and Long-Term Outcome

Monty Lyman , Da-Qing Ma
Section of Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK
J Anesth Perioper Med 2014; 1(2): 122- 124 . Published on Nov 25, 2014 . doi:10.24015/JAPM.2014.0018
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Abstract

It has long been known that patients often experience a state of confusion following surgery, classified as delirium or postoperative cognitive dysfunction (POCD). Although this surgery-induced cognitive dysfunction may predict the progression of dementia in elderly patients, there is little known about the relationship between surgical trauma and the development of chronic neurodegeneration. Recent population evidence suggests that surgery increases the risk of dementia (1), but the biological mechanisms behind this (and related therapeutic targets) are not yet to be fully understood.

 

 

Citation: Monty Lyman, Da-Qing Ma. Surgery, neuroinflammation and long-term outcome. J Anesth Perioper Med 2014; 1: 122-4. doi: 10.24015/JAPM.2014.0018

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