Original Research

Sevoflurane, Laryngeal Mask Airway and Single-Dose Dexmedetomidine: A Better Choice for Patients Undergoing Endovascular Coil Embolization

Wen-Fei Tan , Yan-Hua Jiang , Hong Ma , Jun-Ke Wang
Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, China
J Anesth Perioper Med 2015; 2(3): 153- 157 . Published on May 1, 2015 . doi:10.24015/JAPM.2015.0021
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Background: Patients diagnosed with intracranial aneurysms who undergo endovascular coil embolization (ECE), require sufficient dose of anesthesia to prevent rupture of the aneurysms. However, surgeons often prefer "fast-channel" anesthesia techniques in order to evaluate the effects of the treatment. We designed a double-blind, randomized placebo-controlled study to determine the effects of dexmedetomidine (DEX) on the recovery characteristics of patients who were scheduled to undergo ECE. 

Methods: After intravenous anesthesia induction with propofol, fentanyl and cisatracurium, and laryngeal mask airway insertion, patients were randomly assigned to receive saline (Group C, N=33), 0.5 μg/kg DEX (Group DEX1, N=34), or 1 μg/kg DEX (Group DEX2, N=34). Maintenance of anesthesia was performed using 2 minimum alveolar concentration (MAC) of end-tidal sevoflurane. The length of time for the eyes to open and characteristics of emergence in patients were recorded after the anesthesia was discontinued. 

Results: The incidence of intraoperative bradycardia in Group DEX2 (26.4%) was significantly higher than that in the other groups (15.1% in Group C and 11.8% in Group DEX1). Four patients (12.1%) in Group C exhibited emergence agitation, but it was not observed in any of the patients in the other groups. The length of time for the eyes to open in Group DEX2 was nearly 10 minutes longer than that in the other two groups. 

Conclusions: We concluded that a single-dose of 0.5 μg/kg DEX administered after induction of anesthesia reduced post-sevoflurane agitation in patients undergoing ECE with no adverse effects.



Citation:  Wen-Fei Tan, Yan-Hua Jiang, Hong Ma, Jun-Ke Wang. Sevoflurane, laryngeal mask airway and single-dose dexmedetomidine: a better choice for patients undergoing endovascular coil embolization. J Anesth Perioper Med 2015; 2: 153-7. doi: 10.24015/JAPM.2015.0021

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