Ischemic Stroke Mechanisms, Prevention, and Treatment: The Anesthesiologist’s Perspective

Myles R. McCrary , Song Wang , Ling Wei
Department of Anesthesiology, Emory University School of Medicine Atlanta, GA, USA
J Anesth Perioper Med 2017; 4(2): 76- 86 . Published on Mar 12, 2017 . doi:10.24015/JAPM.2017.0022
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Aim of review: Stroke remains a leading cause of mortality and morbidity. After decades of extensive research, we have gained a detailed understanding of the cellular and molecular mechanisms governing stroke pathophysiology. Despite these advances, few novel and effective treatments have been discovered. Understanding the mechanisms that underlie ischemic brain damage may direct research on future therapies. 

Methods: We reviewed the available literature pertaining to stroke pathology in the past decades and provided brief summaries of the important basic and clinical stroke findings.

Recent findings: This review provided an overview of basic stroke mechanisms and highlighted the main events and processes that lead to cellular demise. We concluded with stroke preventative measures and treatment, highlighting the role of anesthesiologists in preventing perioperative stroke.

Summary: An appreciation of our current understanding of stroke pathology may inform the development of new therapies or preventative measures for stroke, such as anesthetic preconditioning, and lead to optimal perioperative management of patients at high risk for stroke.



Citation: Myles R. McCrary, Song Wang, Ling Wei. Ischemic stroke mechanisms, prevention, and treatment: the anesthesiologist's perspective. J Anesth Perioper Med 2017; 4: 76-86. doi:10.24015/JAPM.2017.0022

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