Review

Perioperative Statin Therapy and the Outcomes of Cardiac Surgery

Chunxia Shi , Nicole A. Weiss , Hong Liu
1Department of Anesthesiology, Chinese Academy of Medical Sciences Fuwai Hospital, Tsinghua University and Peking Union Medical College, National heart center, Beijing, China; 2Department of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, USA., Department of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, USA.
J Anesth Perioper Med 2018; 5(X): x- xx . Published on May 29, 2018 . doi:10.24015/JAPM.2018.0059
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Abstract

Aim of review: Since the discovery in 1976, statins have been widely used in various patient populations, however, the decision on whether to initiate statins in the perioperative setting remains controversial. This article discusses perioperative statin therapy in patients undergoing cardiac surgery.
 
Methods: In this review, we searched literature of the past 2 decades in databases of Embase, PubMed, the Cochrane Library and Science Citation Index, and focused on risks and benefits of perioperative statin therapy in patients undergoing cardiac surgery.
 
Recent findings: While initial studies demonstrated their lipid-lowering effects, recent studies have focused on the pleiotropic effect; an effect which improves endothelial function, reduces vascular inflammation, stabilizes atherosclerotic plaques, inhibits oxidative stress and prevents vascular remodeling. These studies also brought to light the potential benefits of statins in the perioperative setting. In 2014, the American College of Cardiology (ACC) and American Heart Association (AHA) issued a class I recommendation to continue perioperative statins in those already receiving therapy. Recent studies have suggested that statins may also benefit high risk patients undergoing cardiac surgery.  
 
Conclusion: Most studies have shown that perioperative statin therapy can reduce incidence of major cardiovascular events, including myocardial infarction, atrial fibrillation, infection, stroke and death for patients undergoing cardiac surgery. (Funded by the University of California Davis Health Department of Anesthesiology and Pain Medicine, and the National Institutes of Health (NIH)).
 
 
 
 
 

Citation: Chunxia Shi, Nicole A. Weiss, Hong Liu. Perioperative Statin Therapy and the Outcomes of  Cardiac Surgery. J Anesth Perioper Med 2018;5: x- xx. doi: 10.24015/JAPM.2018.0059

This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

 

 

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